Coptis Chinensis root
Coptis Chinensis (also known as Rhizoma coptidis) contains several phytochemicals (molecules produced by plants) that can reduce cellular stress and improve pancreas health (1 and 2).
Astragalus root
Specific phytochemical components in Astragalus can reduce cellular stress and improve pancreas health (3). More importantly, when combined with Coptis Chinensis, the effect of Astragalus on relieving Insulin-Resistance synergizes (4). Astragalus has many health benefits, including immune-boosting, anti-aging, and anti-inflammatory effects (5).
Gynostemma Pentaphyllum
Jiaogulan can improve insulin sensitivity in Type 2 diabetic people (6). It is also an AMPK activator that increases metabolism in our bodies.
Citrus Bioflavonoids and Rhodiola rosea
Both are potent antioxidants. They can alleviate oxidative stress, a leading risk to pancreatic beta cell health.
Refererences:
1. Rhizoma coptidis as a Potential Treatment Agent for Type 2 Diabetes Mellitus and the Underlying Mechanisms: A Review. Front Pharmacol. 2019 Jul 22;10:805. doi: 10.3389/fphar.2019.00805.
2. Cellular stress response mechanisms of Rhizoma coptidis: a systematic review. Chin Med. 2018 Jun 7;13:27. doi: 10.1186/s13020-018-0184-y.
3. Recent Advances in Astragalus membranaceus Anti-Diabetic Research: Pharmacological Effects of Its Phytochemical Constituents. Evid Based Complement Alternat Med. 2013;2013:654643. doi: 10.1155/2013/654643.
4. Combined Use of Astragalus Polysaccharide and Berberine Attenuates Insulin Resistance in IR-HepG2 Cells via Regulation of the Gluconeogenesis Signaling Pathway. Front Pharmacol. 2019 Dec 23;10:1508.
5. Based on network pharmacology to explore the molecular mechanisms of astragalus membranaceus for treating T2 diabetes mellitus. Ann Transl Med. 2019 Nov;7(22):633. doi: 10.21037/atm.2019.10.118.
6. Hypoglycemic effect of Gynostemma pentaphyllum saponins by enhancing the Nrf2 signaling pathway in STZ-inducing diabetic rats. Arch Pharm Res. 2016 Feb;39(2):221-230. doi: 10.1007/s12272-014-0441-2. Epub 2014 Jul 29.